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2, 6-dihydroxybenzoic acid and dichlorosulfoxide were mixed evenly. Under the condition of 200r/min and 85℃ for reflux reaction for 10h, dichlorosulfoxide was removed by distillation and benzoic acid and aluminum trichloride were added. Under the condition of 300r/min and 25℃ for 40min, after the reaction, The intermediate was prepared after 2h reaction at 75℃.
After evenly mixing p-methylphenol, potassium carbonate, dimethyl sulfate and acetone, the intermediate was prepared by stirring reflux for 5h at the rotational speed of 200r/min and the temperature of 100℃. The intermediate was prepared by mixing the intermediate, potassium permanganate and deionized water evenly, and the intermediate was prepared by reflux reaction for 5h at the temperature of 120℃. The intermediate and dichlorosulfone were mixed evenly, and the reaction was carried out for 10h under the condition of 200r/min and 85℃, then the dichlorosulsulfone was removed by distillation, and diazo liquid was added. The intermediate was prepared after 1.5h reaction under the condition of 300r/min, 10℃ and ph of the reaction liquid.
The intermediate, hydrogen bromide solution and tetrahydrofuran were mixed evenly, and the temperature was 130℃ for reflux reaction for 5h to prepare the intermediate. After mixing the intermediate, ethanol and sodium hydroxide solution evenly, hydrazine hydrate was added at 200r/min and 90℃ for 8h. After the reaction, the ph value of the reaction solution was adjusted to 8. The intermediates,n, N-dimethylformamide and sodium hydroxide were mixed evenly. Under the condition of rotating speed of 500r/min and temperature of 50℃, the reaction was carried out for 5h to prepare the anti-aging agent.
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